Diagnosis and Treatment Bacterial Keratitis


  • Devina Hardianto Universitas Lampung
  • Devira Fitriani Kamal
  • Mochamad Fauzan Dava
  • Rani Himayani
  • Putu Ristyaning Ayu Sangging




Bacterial Keratitis, Manajement, Diagnosis, Keratitis, Kornea Ulcer


Bacterial keratitis is an infection of the cornea that caused by the invasion and proliferation of bacteria in the cornea, which can cause ulceration of the cornea. Bacterial keratitis is most often caused by Staphylococcus aureus, Staphylococcus epidermis, Streptococcus pneumoniae, and Pseudomonas aeruginosa. The use of contact lenses is associated with the incidence of bacterial keratitis. Other risk factors are alcohol, malnutrition, trauma, changes in the surface of the cornea. Symptoms that are often experienced are pain and red eyes, blurred vision, sensitivity to light, watery eyes, and tearing, because of damage in corneal epithelium and stromal inflammation due to the entry of bacteria. It is necessary to establish the diagnosis of bacterial keratitis. Evaluation is by inspection of the eye using slit lamp. Conjunctival injection, white infiltrate on the cornea due to damage to the corneal epithelium can be found. In addition, corneal thinning, stromal edema, inflammatory endothelial plaques, folds of Descemet's membrane, mucopurulent discharge, and anterior chamber hypopyon were also found. Laboratory test is through a scraping of the cornea for gram staining or bacteria culture. The treatment of bacterial keratitis is using broad-spectrum antibiotics before culture test and definitive antibiotics after the causative bacteria are identified.


Miller, D., Cavuoto, K.M., Alfonso, E.C. Bacterial Keratitis. In: Das, S., Jhanji, V. (eds) Infections of the Cornea and Conjunctiva. Singapore : Springer ; 2021

Sawitri PA.. Keratitis [Telaah Jurnal]. Kendari : Universitas Halu Oleo ; 2021

Tuft, S., Somerville, T. F., Li, J. O., Neal, T., De, S., Horsburgh, M. J., Fothergill, J. L., Foulkes, D., & Kaye, S. Bacterial keratitis: identifying the areas of clinical uncertainty. Progress in retinal and eye research. 2022; 89: 101031.

Gurnani B, Kaur K. Bacterial Keratitis. Treasure Island (FL) : StatPearls ; 2022

Deschenes J. Bacterial Keratitis. Medscape; 2019

Apriliona, P. F., Sunariasih, N., & Ningrum, R. K. Hubungan Lama Pemakaian Soft Contact Lens dengan Keluhan Sindrom Mata Kering. Aesculapius Medical Journal. 2022 :1(2) : 52

Handayani, A. D. Kajian Sistematik: Identifikasi Patogen Penyebab Biofilm Associated Keratitis (Keratitis Kronik) Pada Pengguna Lensa Kontak. [Doctoral Disertasi]. Makassar: Universitas Hasanuddin ; 2021

Ting, D., et al. Infectious Keratitis: An Update on Epidemiology, Causative Microorganisms, Risk Factors, and Antimicrobial Resistance. Eye. London, England. 2021; 35(4), pp. 1084–101.

American Academy of Ophthalmology. Photokeratitis. 2022.

Austin A, Lietman T, Rose-Nussbaumer J. Update on the Management of Infectious Keratitis. Ophthalmology. 2017;124(11):1678–89

Upadhyay MP, Srinivasan M, Whitcher JP. Diagnosing and managing microbial keratitis. Community Eye Heal J. 2015;28(89):3–6.

Deschenes J. Bacterial Keratitis [internet]. Medscape; 2019. [disitasi tanggal 10 Maret 2023]. Tersedia dari: https://emedicine.medscape.com/article/1194028-overview

Lin A, Rhee MK, Akpek EK, Amescua G, Farid M, Garcia-Ferrer FJ, Varu DM, Musch DC, Dunn SP, Mah FS; American Academy of Ophthalmology Preferred Practice Pattern Cornea and External Disease Panel. Bacterial Keratitis Preferred Practice Pattern®. Ophthalmology. 2019 Jan;126(1):P1-P55. doi: 10.1016/j.ophtha.2018.10.018. Epub 2018 Oct 23. PMID: 30366799.

Tuft S, Somerville TF, Li JO, Neal T, De S, Horsburgh MJ, Fothergill JL, Foulkes D, Kaye S. Bacterial keratitis: identifying the areas of clinical uncertainty. Prog Retin Eye Res. 2022 Jul;89:101031. doi: 10.1016/j.preteyeres.2021.101031. Epub 2021 Dec 13. PMID: 34915112.

Katzung, BG, Masters, SB, Trevor AJ, Farmakologi Dasar & Klinik Vol.2. Edisi ke-12, Jakarta: Penerbit Buku Kedokteran EGC; 2014

Gurnani B, Kaur K. Bacterial Keratitis [Internet]. Treasure Island (FL): StatPearls Publishing; 2022 [diperbarui 6 Desember 2022; disitasi tanggal 10 Maret 2023]. Tersedia dari: https://www.ncbi.nlm.nih.gov/books/NBK574509/

Gokhale NS. Medical management approach to infectious keratitis. Indian J Ophthalmol. 2008;56(3):215-20.

M, İrkeç M. The Value of Fortified Aminoglycoside/Cephalosporin Treatment as First-Line Treatment and in Fluoroquinolone-Resistant Bacterial Keratitis. Turk J Ophthalmol. 2020 30;50(5):258-263.

Hanet, Marie-Sophie; Jamart, Jacques; Pinheiro Chaves, Alessandra. Fluoroquinolones or fortified antibiotics for treating bacterial keratitis: systematic review and meta-analysis of comparative studies. Canadian Journal of Ophthalmology / Journal Canadien d'Ophtalmologie. 2012;47(6), 493–499.

Austin A, Lietman T, Rose-Nussbaumer J. Update on the Management of Infectious Keratitis. Ophthalmology. 2017;124(11):1678-1689.

Palioura S, Henry CR, Amescua G, Alfonso EC. Role of steroids in the treatment of bacterial keratitis. Clin Ophthalmol. 2016; 27;10:179-86.

Srinivasan, Muthiah. Corticosteroids for Bacterial Keratitis. Archives of Ophthalmology. 2012; 130(2), 143–.

Blair, Jason; Hodge, William; Al-Ghamdi, Saeed; Balabanian, Rita; Lowcock, Beth; Pan, Yi Irene; Sherif, Hesham; AlMahmoud, Tahra; Fergusson, Dean; Slomovic, Allan. Comparison of antibiotic-only and antibiotic-steroid combination treatment in corneal ulcer patients: double-blinded randomized clinical trial. Canadian Journal of Ophthalmology / Journal Canadien d'Ophtalmologie. 2011;46(1), 40–45.



How to Cite

Hardianto, D., Kamal, D. F., Dava, M. F., Himayani, R., & Sangging, P. R. A. . (2023). Diagnosis and Treatment Bacterial Keratitis. Medical Profession Journal of Lampung, 13(4.1), 63-70. https://doi.org/10.53089/medula.v13i4.1.712

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