Case Report: Administration of Misoprostol in Incomplete Abortion Cases


  • Siti Shafira Elfreda Universitas Lampung
  • Lintang Lestari Cahya Sawitri Universitas Lampung
  • Nabila Yoli Rahmadani Universitas Lampung
  • Zulfadli Zulfadli Universitas Lampung



Keywords: incomplete abortion, misoprostol, drug of choice


Abortion refers to the termination of pregnancy before 20 weeks of gestation or when the fetal weight is below 500 grams, typically due to fetal non-viability outside the uterus. Globally, there are over 2.3 million cases reported annually. Incomplete abortion is characterized by the presence of an open cervical ostium and bleeding, where all the products of conception are incompletely expelled from the uterus or do not correspond with the expected gestational age. This case study reports on incomplete abortion in a 26-year-old nulligravid woman presenting with vaginal bleeding. Clot discharge indicated expulsion of conception products, leading to a diagnosis of incomplete abortion at 12 weeks and 9 days of gestation (G1P0A0). Currently, misoprostol remains the preferred pharmacological intervention as Drug of Choice in cases of incomplete abortion. However, in practice, there are several ways to administer misoprostol, either sublingually, orally or vaginally. Several health organizations have their own protocols for administering misoprostol for cases of incomplete abortion. This case report will discuss misoprostol administration in patients with incomplete abortion.


Akbar dan Aidil. Faktor penyebab abortus di Indonesia tahun 2010-2019: Studi meta analisis. Jurnal Biomedik: JBM. 2019; 11(3).

Kementerian Kesehatan RI. Direktorat Jenderal Kesehatan Masyarakat Pedoman Nasional Asuhan Pasca Keguguran yang Komprehensif. Jakarta: Kementerian Kesehatan RI. 2020.

Musik T, Grimm J, Juhasz-Böss I, Bäz E. Treatment options after a diagnosis of early miscarriage: Expectant, medical, and urgical. Dtsch Arztebl Int. 2021; 118(46):789-794. doi: 10.3238/arztebl.m2021.0346. PMID:34696822; PMCID: PMC8864670.

American College of Obstetricians and Gynecologists’ Committee on Practice Bulletins-Gynecology. ACOG Practice Bulletin No. 200: Early pregnancy loss. Obstet Gynecol. 2018; 132(5): e197-e207.

World Health Organization. Human Reproduction Programme. Abortion Care Guideline. World Health Organization. 2023.

Practice Committee of the American Society for Reproductive Medicine. Evaluation and treatment of recurrent

pregnancy loss: a committee opinion. Fertil Steril. 2012; 98(5): 1103-11.

Redinger A., Nguyen H. Incomplete Miscarriage. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2024. Available from: 559071/

Marwah S, Gupta S, Batra NP, Bhasin V, Sarna V, Kaur N. A Comparative Study to Evaluate the Efficacy of Vaginal vs Oral Prostaglandin E1 Analogue (Misoprostol) in Management of First Trimester Missed Abortion. Journal of clinical and diagnostic research: JCDR. 2016; 10(5): QC14–QC18. 8.7891

Souizi B, Akrami R, BorzoeeF, Sahebkar M. Comparison of the efficacy of sublingual, oral, and vaginal administration of misoprostol in the medical treatment of missed abortion during first trimester of pregnancy: A randomized clinical trial study. Journal of research in medical sciences: the official journal of Isfahan University of Medical Sciences. 2020; 25(1):72. 9

Khairnar MM, Patil AM. Study of the efficacy and success rate of single dose oral mifepristone and vaginal misoprostol v/s vaginal misoprostol alone for second trimester termination of pregnancy. MVP J Med Sci. 2019; 5:216–21.

Imširija N, Imširija L, Godinjak Z, Deković S, El Ardat MA. Contemporary treatment of pathological pregnancies in the first trimester. Med J. 2015; 21:34–7.

Rahimi M, Haghighi L, Baradaran HR, Azami M, Larijani SS, Kazemzadeh P, et al. Comparison of the effect of oral and vaginal misoprostol on labor induction: updating a systematic review and meta- analysis of interventional studies. Eur J Med. 2023; 28 (51): 1- 01007-8

Hitzeman N dan Albin K. Misoprostol for incomplete first trimester miscarriage.American family physician. 2014; 89(7):




How to Cite

Siti Shafira Elfreda, Sawitri, L. L. C. ., Rahmadani, N. Y. ., & Zulfadli, Z. (2024). Case Report: Administration of Misoprostol in Incomplete Abortion Cases. Medical Profession Journal of Lampung, 14(6), 1051-1055.




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