Fibrous dysplasia


  • Helmi Ismunandar
  • Rani Himayani



Fibrous dysplasia,, diagnosis, treatment


Fibrous dysplasia is a benign intramedullary fibro-oseus lesion. Fibrous dysplasia occurs from the post-zygotic somatic activation (gain-of-function) mutation in GNAS, which encodes the G-protein associated with the AMP pathway, Gsα. Involvement of the skin, bone, and endocrine system is consistent with mutation events early in embryogenesis, which occur prior to differentiation of the 3 embryonic layers. The diagnosis can only be made after a thorough evaluation of the degree of skeletal disease that is monostotic / polyostotic and the presence of extra-skeletal manifestations. Monostotic fibrous dysplasia is defined as the presence of fibrous dysplasia at only one skeleton site. Polyostotic fibrous dysplasia is defined as the presence of fibrous dysplasia at more than one skeletal site without extra-skeletal manifestations. Examination can be done with plain radiographs or CT scans which are useful for determining the direction of malignancy. Lifestyle optimization is the main target of fibrous dysplasia therapy. Medical treatment is recommended to reduce pain, stabilize lesions, and support bone structures to avoid fractures. While surgical therapy is preferred in treating deformities, to avoid pathological fractures, and to treat symptomatic lesions. Malignant transformation in FD is very rare but routine follow-up should be done.


Javaid MK, Boyce A, Appelman-dijkstra N, Ong J, Defabianis P, Offiah A, et al. Best practice management guidelines for fibrous dysplasia / McCune-Albright syndrome : a consensus statement from the FD / MAS international consortium. Orphanet J Rare Dis. 2019;9(14):1–17.

Rageh OA. Fibrous Dysplasia-A review Article. IOSR-JDMS. 2018;16(12):54–60.

Riddle ND, Bui MM. Fibrous Dysplasia. Arch Pathol Lab Med. 2013;137(January):134–8.

Mohan H, Mittal P, Mundi I, Kumar S. Fibrous dysplasia of bone : a clinicopathologic review. Pathol Lab Med Int. 2014;(3):31–42.

Boyce AM. Fibrous Dysplasia. StatPearls. 2019;1–8.

DICAPRIO MR, WILLIAM F. ENNEKING. Current Concepts Review Fibrous Dysplasia. J BONE Jt Surg. 2005;87A(8):1848–64.

Lloyd T, Berridge NL. Fibrous Dysplasia. In: Maxillofacial Surgery [Internet]. Third Edit. Elsevier Inc.; 2017. p. 1358–67. Available from:

Anitha N, Sankari SL, Malathi L, Karthick R. Fibrous dysplasia ‑ recent concepts. J Pharm Bioallied Sci. 2015;7(April):171–3.

ÖZŞEN M, YALÇINKAYA Ü, BILGEN MS, YAZICI Z. Fibrous Dysplasia : Clinicopathologic Presentation of 36 Cases. Turk Patoloji Derg. 2018;1(34):234–41.

Leet AI, Collins MT. Current approach to fibrous dysplasia of bone and McCune – Albright syndrome. J Child Orthop. 2007;(1):3–17.



How to Cite

Arrohmansyah, D. ., Helmi Ismunandar, & Rani Himayani. (2021). Fibrous dysplasia. Medical Profession Journal of Lampung, 11(1), 135-140.




Most read articles by the same author(s)

1 2 3 > >>