The Usage Comparison of Chloramphenicol and Levofloxacin as Therapy for Bacterial Conjunctivitis


  • Alfina Indah Nabila Lampung University
  • yusran universitas lampung
  • rasmi zakiah oktarlina universitas lampung



Bacterial Conjunctivitis, Staphylococcus aureus, Chloramphenicol, Levofloxacin


Conjunctivitis is one of the most common eye diseases. Bacterial conjunctivitis ranks second after viral conjunctivitis as the most common cause of infectious conjunctivitis. Bacterial conjunctivitis can affect anyone of all ages, both men and women. One of the non-gonococcal bacteria that often causes eye infections is Staphylococcus aureus. Staphylococcus aureus generally affects adults more often than children Although rarely causes severe complaints, bacterial conjunctivitis can interfere with daily activities such as work or school. Bacterial conjunctivitis usually resolves on its own within 7 days but may continue for up to 2 weeks. Prescribing antibiotics in bacterial conjunctivitis can reduce complaints in patients and can also speed up healing. Selection of the right antibiotic is very important in order to obtain the desired treatment results. Chloramphenicol and levofloxacin are antibiotics with a broad spectrum that can be an option for the treatment of bacterial conjunctivitis caused by Staphylococcus aureus bacteria.


Paulsen F, Waschke J. Sobotta: atlas anatomi manusia. Edisi ke-24. Singapura: Elsevier; 2019.

Mantadakis E, Maraki S, Michailidis L, Gitti Z, Pallikaris I, Samonis G. Antimicrobial susceptibility of Gram-positive cocci isolated from patients with conjunctivitis and keratitis in Crete, Greece. Journal of Microbiology, Immunology and Infection. 2013;46(1):1721-1729.

American Academy of Ophthalmology. Conjunctivitis Preferred Practice Pattern. America: Elsevier Inc.; 2018.

CDC, causes of pink eye (conjunctivitis) [Internet]. Centers for Disease Control and Prevention; 2019 [disitasi tanggal 28 September 2021]. Tersedia dari:

Khanal A, Sulochan G, Gaire A, Khanal A, Estrada R, Ghimire R, et al. Methicillin-resistant Staphylococcus aureus in Nepal: A systematic review and meta-analysis. International Journal of Infectious Diseases. 2020;103:48–55.

Mohamed S, Elmohamady M, Abdelrahman S, Amer M, Abdelhamid A. Antibacterial effects of antibiotics and cell-free preparations of probiotics against Staphylococcus aureus and Staphylococcus epidermidis associated with conjunctivitis. Saudi Pharmaceutical Journal. 2020;28(12):1558-1565.

Ryder E, Benson S. Conjunctivitis [Internet]. StatPearls; 2021 [diperbarui tanggal 11 Agustus 2021; disitasi tanggal 20 Oktober 2021]. Tersedia dari:

Pippin M, Le J. Bacterial Conjunctivitis [Internet]. StatPearls; 2021 [diperbarui tanggal 2 Juli 2021; disitasi tanggal 20 Oktober 2021]. Tersedia dari:

Ilyas S, Yulianti SR. Ilmu penyakit mata Edisi ke-5. Jakarta:Badan Penerbit FKUI;2015.

Høvding G. Acute bacterial conjunctivitis. Acta Ophthalmologica. 2008;86(1):5-17.

Ryder E, Benson S, Price K. Conjunctivitis: Nursing [Internet]. StatPearls; 2021 [diperbarui tanggal 11 Agustus 2021; disitasi tanggal 20 Otober 2021]. Tersedia dari:

Health Protection Suveillance Centre. Conjunctivitis antibiotic prescribing [Internet].; 2021 [disitasi tanggal 21 Oktober 2021]. Tersedia dari:

Oong G, Tadi P. Chloramphenicol [Internet]. StatPearls; 2021 [diperbarui tanggal 29 September 2021; disitasi tanggal 20 Oktober 2021]. Tersedia dari:

Katzung B, Masters S, Trevor A. Basic & clinical pharmacology. Edisi ke-12. New York: McGraw-Hill Medical; 2012.

American Academy of Ophthalmology. Bacterial conjunctivitis - EyeWiki [Internet]. America: American Academy of Ophthalmology; 2021 [disitasi tanggal 21 Oktober 2021]. Tersedia dari:

Podder V, Sadiq N. Levofloxacin [Internet]. StatPearls; 2021 [diperbarui tanggal 22 September 2021; disitasi tanggal 21 Oktober 2021]. Tersedia dari:

Watanabe R. Fluoroquinolone antibacterial eye drops: effects on normal human corneal epithelium, stroma, and endothelium. Clinical Ophthalmology. 2010;1181.

Iwalokun B, Oluwadun A, Akinsinde K, Niemogha M, Nwaokorie F. Bacteriologic and plasmid analysis of etiologic agents of conjunctivitis in Lagos, Nigeria. Journal of Ophthalmic Inflammation and Infection. 2011;1(3):95-103.



How to Cite

Alfina Indah Nabila, yusran, & rasmi zakiah oktarlina. (2022). The Usage Comparison of Chloramphenicol and Levofloxacin as Therapy for Bacterial Conjunctivitis. Medical Profession Journal of Lampung, 11(4), 353-356.




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