Ricinus Communis L. Leaf Extract As Antimicroba: Development Of New Antimicrobials Against MDR Microbes


  • Nurul Annisa Azmy




Microba multidrug-resistant, natural antimicrobials, Ricinus communis L. leaf extract


The emergence of microbes multidrug-resistant (MDR), caused by overuse of antibiotics, induce a dramatic decrease in the efficacy of antimicrobial drugs. Natural products can be used as exploration and development of new antimicrobials. Plants are a natural source that contains ingredients for traditional medicines. Plants are a source of phytochemical with various bio-structures and effective bioactivity against a number of diseases including bacterial infectious diseases. More than 80% of the world's total population relies on herbal medicines to meet their primary health care needs. The use of plants as alternative medicine is widely used by the community, in addition to being easily available, these medicinal plants rarely have side effects such as synthetic drugs. Extracts from plants are widely used by humans for various purposes including solving human health problems for example, herbal medicines used their antimicrobial properties to treat other diseases due to the activity of secondary metabolites contained in them. One of the herbs that is believed to be antimicrobial, namely Ricinus communis L. Jarak Kepyar or Ricinus communis L. is a plant that easy to grow in the field or in open areas, is resistant to drought and can grow in various soil conditions. Ricinus communis L. leaf extract contains various kinds of phytochemical compounds which play a role in inhibiting bacterial growth. The mechanism of inhibition of bacterial growth occurs through inhibition of the synthesis of microbial cell walls so that microbes will die.


Lailia YN. Uji aktivitas antibakteri ekstrak etanolik daun jarak (ricinus communis l.) terhadap pertumbuhan staphylococcus aureus dan pseudomonas aeruginosa. Surakarta: Fakultas Ilmu Kesehatan Universitas Setia Budi; 2019.

Hajrah N, Abdul WM, Sabir J, Al-Garni SMS, Sabir M, El-hamidy, Dkk. Anti-bacterial activity of Ricinus communis L. against bacterial pathogens Escherichia coli and Klebsiella oxytoca as evaluated by Transmission electron microscopy. Biotechnology and Biotechnological Equipment. 2018;32(3):686-691.

Jena J, dan Gupta AK. Ricinus communis linn: A phytopharmacological review. International Journal of Pharmacy and Pharmaceutical Sciences. 2012; 4(4):25-29.

More P, Rathod G, dan Pandhure N. Phytochemical Analysis and Antibacterial Activity in Ricinus Communis L. Periodic Research. 2014;3(1): 49–51.

Safriana J, Nurhamidah, Handayani D. Uji aktivitas antioksidan dan antibakteri ekstrak daun ricinus communis L (jarak kepyar). Jurnal Pendidikan dan Ilmu Kimia. 2017;1(1):66-70.

WHO. Antimicrobial resistance: global report on surveillance; 2014.

Magiorakos AP, Srinivasan A, Carey, RB, Dkk. Multidrug-resistant, extensively drug-resistant and pandrug-resistant bacteria: an international expert proposal for interim standard definitions for acquired resistance. European Society of Clinical Microbiology and Infectious Diseases, CMI. Clinical Microbiology and Infection. 2011;18(3): 268–281.

Quave CL. Antibiotics from nature: traditional medicine as a source of new solutions for combating antimicrobial resistance. Emory University, Atlanta, GA, USA; 2016.

Kenneth G, Ngwoke, Damian C, Odimegwu, Dkk. Antimicrobial natural products. Science against microbial pathogens: communicating current research and technological advances A; 2011.

Wibowo TN. Efek mortalitas ekstrak biji jarak (Ricinus communis L.) terhadap larva aedes aegypti l. Surakarta: Fakultas Kedokteran Universitas Sebelas Maret. 2010.

Kumar M. A review on phytochemical constituents and pharmacological activities of ricinus communis l. plant. International Journal of Pharmacognosy and Phytochemical Research. 2017; 9(4); 466-472.

Rumape O. Isolasi dan identifikasi senyawa antifeedant dari daun jarak kepyar (ricinus communis l) terhadap kumbang Epilachna Varivestis mulsant. Gorontalo: Universitas Negeri Gorontali; 2013.

Hashem R, Saeid S, Abdorrasoul M, dan Farzaneh F. Antimicrobial Activity of Castor Oil Plant (Ricinus communis) Seeds Extract Against Gram Positive Bacteria, Gram Negative Bacteria and Yeast. International Journal of Molecular Medicine and Advance Sciences. 2015;11(1): 9-12.

Suurbaar J, Mosobil R, dan Donkor AM. Antibacterial and antifungal activities and phytochemical profile of leaf extract from different extractants of Ricinus communis against selected pathogens. BMC Research Notes. 2017;10(1): 1–6.

Naz R, dan Bano A. Antimicrobial potential of Ricinus communis leaf extracts in different solvents against pathogenic bacterial and fungal strains. Asian Pacific Journal of Tropical Biomedicine. 2012.2(12): 944–947.

Zore GB, Thakre AD, Jadhav S, Karuppayil SM. Terpenoids inhibit Candida albicans growth by affecting membrane integrity and arrest of cell cycle. Phytomedicine. 2011;18: 1181–1190.

Sulastri, H. Aktivitas antimikroba ekstrak metanol daun jarak kepyar (ricinus communis l.) terhadap aspergillus niger. Bogor: Departemen Hasil Hutan Fakultas Kehutanan Institut Pertanian BogorL;2016.



How to Cite

Nurul Annisa Azmy. (2020). Ricinus Communis L. Leaf Extract As Antimicroba: Development Of New Antimicrobials Against MDR Microbes. Medical Profession Journal of Lampung, 10(3), 443-447. https://doi.org/10.53089/medula.v10i3.92