Risk Factor Analysis of Mortality Among Sepsis Patients in the Intensive Care Unit of RSUD Dr. H. Abdul Moeloek, Lampung (2018–2021)
DOI:
https://doi.org/10.53089/medula.v16i2.1788Keywords:
Age, Comorbid Disease, Glasgow Coma Scale, Mean Arterial Pressure, MortalityAbstract
Sepsis is an organ dysfunction due to dysregulation of infection response. It is characterized by cardinal inflammatory signs such as vasodilation, leukocyte accumulation, and increased microvascular permeability in tissues away from the site of infection. Sepsis is identified using clinical criteria, specifically the Sequential (Sepsis-Related) Organ Failure Assessment Score with ≥2 points. Sepsis is a leading cause of mortality in the Intensive Care Unit. Its mortality is triggered by several risk factors, including age, low Glasgow Coma Scale and Mean Arterial Pressure scores, and the presence of comorbidities. This study aims to analyze the relationship between these determinants and mortality among the Intensive Care Unit sepsis patients. This study used an observational analytic method with a cross-sectional approach. The subjects were sepsis patients in the Intensive Care Unit of RSUD DR. H. Abdul Moeloek Lampung in 2018-2021 who met the inclusion and exclusion criteria. The independent variables were age, Glasgow Coma Scale, Mean Arterial Pressure, and comorbidities, while the dependent variable was mortality. Samples were collected using total sampling technique. The results showed that age, Glasgow Coma Scale, Mean Arterial Pressure, and comorbid disease were significantly associated sepsis mortality, with p-values of 0.008, 0.029, 0.040, and 0.013, respectively. Thus, there is a relationship between age, Glasgow Coma Scale, Mean Arterial Pressure, and comorbid disease to the mortality among sepsis patients.
References
World Health Organization. Global report on the epidemiology and burden of sepsis: current evidence, identifying gaps and future directions. Geneva: World Health Organization; 2020.
Akbar I, Widjajanto E, Fathoni M. Faktor dominan dalam memprediksi mortalitas pasien dengan sepsis di unit gawat darurat. J Kedokt Brawijaya. 2018;30(2):153–158. doi:10.21776/ub.jkb.2018.030.02.14.
Hatman FA, Semedi BP, Budiono B. Analisis faktor risiko terhadap lama perawatan pasien sepsis yang meninggal di ruang perawatan intensif RSUD Dr. Soetomo Surabaya. J Anestesiol Indones. 2021;13(2):78–87. doi:10.14710/jai.v13i2.32441.
Sidharti L, Zainal R, Zulkifli, Hafy Z. Receptor interacting protein kinase 3 sebagai prediktor kematian 28 hari pasien sepsis di RSUP Dr. Mohammad Hoesin Palembang. Anesth Crit Care. 2020;38(1):61–69.
Dinas Kesehatan Provinsi Lampung. Profil Kesehatan Provinsi Lampung tahun 2020. Bandar Lampung: Dinkes Provinsi Lampung; 2021.
Evans L, Rhodes A, Alhazzani W, Antonelli M, Coopersmith CM, French C, et al. Surviving sepsis campaign: international guidelines for management of sepsis and septic shock 2021. Crit Care Med. 2021;49(11):e1063–e1143. doi:10.1097/CCM.0000000000005337.
Singer M, Deutschman CS, Seymour CW, Shankar-Hari M, Annane D, Bauer M, et al. The third international consensus definitions for sepsis and septic shock (Sepsis-3). JAMA. 2016;315(8):801–810. doi:10.1001/jama.2016.0287.
Tambajong RN, Lalenoh DC, Kumaat L. Profil penderita sepsis di ICU RSUP Prof. Dr. R. D. Kandou Manado periode Desember 2014–November 2015. J E-Clinic. 2016;4(1). doi:10.35790/ecl.v4i1.11011.
Alalawi MSM, Aljabran HAM, Alkhamri AM, Alwahbi AM, AlQarrash ZI, Iraqi HAM. Glasgow coma scale in anticipation of sepsis and septic shock: a review article. Egypt J Hosp Med. 2017;69(6):2663–2666. doi:10.12816/0042245.
Leone M, Asfar P, Radermacher P, Vincent JL, Martin C. Optimizing mean arterial pressure in septic shock: a critical reappraisal of the literature. Crit Care. 2015;19(1):101. doi:10.1186/s13054-015-0794-z.
Katu S, Suwarto S, Pohan HT, Abdullah M. Faktor-faktor yang mempengaruhi keberhasilan terapi antibiotik empirik pada pasien sepsis berat dan syok sepsis. J Penyakit Dalam Indones. 2015;2(2). doi:10.7454/jpdi.v2i2.72.
Nasir N, Jamil B, Siddiqui S, Talat N, Khan FA, Hussain R. Mortality in sepsis and its relationship with gender. Pak J Med Sci. 2015;31(5):1201–1206. doi:10.12669/pjms.315.6925.
Astutik AW, Annisa N, Rusli R, Ibrahim A. Kesesuaian pemilihan antibiotik empiris pada pasien sepsis di RSUD Abdul Wahab Sjahranie Samarinda. Proc Mulawarman Pharm Conf. 2017. doi:10.25026/mpc.v5i1.219.
Wicaksono A, Adisasmita A, Harijanto E. Frekuensi dan mortalitas pasien sepsis dan syok septik di ICU rumah sakit swasta tipe B di Tangerang Selatan. J Epidemiol Kesehat Indones. 2022;6(1):27–36.
Yudhorini LT, Komalasari Y, Azifitria, Novanti L. Evaluasi penggunaan antibiotik pada pasien sepsis dengan COVID-19 di RSUP Fatmawati Jakarta. J Farmasi Klinik-Base Pract. 2022;1(1).
Manapa AM. Karakteristik penderita sepsis yang dirawat di beberapa rumah sakit di Indonesia periode 2003–2019. Makassar: Universitas Bosowa; 2020.
Aryana IS. Pemberian antimikrobial pada sepsis lanjut usia. Denpasar: Udayana University Press; 2018.
Kattouf N, Assaf M, Haidar S, Bachir R, El Sayed M, BouChebl R. Risk factors for mortality among septic trauma patients. Emerg Med Int. 2022;2022:6386078. doi:10.1155/2022/6386078.
Thooft A, Favory R, Salgado DR, Taccone FS, Donadello K, De Backer D, et al. Effects of changes in arterial pressure on organ perfusion during septic shock. Crit Care. 2011;15(5):R222. doi:10.1186/cc10462.
Darwis I, Asdie RH. Vasopressin pada manajemen syok septik. J Medula. 2021;11(3):313–320.
Gunawan B, Pangalila F, Ludong M. Hubungan tingkat keparahan sepsis dengan diabetes melitus berdasarkan HbA1c. Tarumanagara Med J. 2019;1(2):277–290. doi:10.24912/TMJ.V1I2.3827.
Rhee C, Jones TM, Hamad Y, Pande A, Varon J, O’Brien C, et al. Prevalence, causes, and preventability of sepsis-associated mortality in US hospitals. JAMA Netw Open. 2019;2(2):e187571. doi:10.1001/jamanetworkopen.2018.757
Adani SD, Zulfariansyah A, Santoso PTR. Quality assessment of antibiotic prescription for sepsis treatment in ICU. Althea Med J. 2017;4(2):286–292. doi:10.15850/amj.v4n2.1088.
Sewalt CA, Venema E, Wiegers EJA, Lecky FE, Schuit SCE, den Hartog D, et al. Trauma models to identify major trauma and mortality in prehospital setting. Br J Surg. 2020;107(4):373–380. doi:10.1002/bjs.11304.
Noegroho BS, Adi K, Mustafa A, Haq RS, Wijayanti Z, Liarto J. Role of qSOFA score in predicting Fournier gangrene mortality. Asian J Urol. 2021. doi:10.1016/j.ajur.2021.11.003.
Sari EK, Hayati YS, Rokhmawati NL. Hubungan skor SOFA dengan mortalitas pasien sakit kritis. Maj Kesehat. 2021;8(3):149–155. doi:10.21776/ub.majalahkesehatan.2021.008.03.4.
Kuragayala SD, Ganti SR, Sirga S, Kommula HB. Ideal mean arterial pressure target in septic shock: the hunt goes on. Saudi J Med. 2019;4(8). doi:10.36348/sjm.2019.v04i08.021.
Downloads
Published
How to Cite
Issue
Section
License
Copyright (c) 2025 Medical Profession Journal of Lampung
This work is licensed under a Creative Commons Attribution-ShareAlike 4.0 International License.
