Effectiveness of Non-Pharmacologic Therapy in Hypertensive Patients


  • Nadiya Widda Mawaddah Medical Faculty, Lampung university
  • Ervina Damayanti Universitas Lampung
  • Citra Yuliyanda Pardilawati Universitas Lampung




Diastolic, Hypertension, Literature review, Non-pharmacologic therapy, Sistolic.


Hypertensive disease is the leading cause of early death worldwide. Hypertension is a common chronic medical condition characterized by sustained increases in arterial pressure. The high risk of side effects in the use of antihypertensive medicine for a long period of time causes non-pharmacological therapy of hypertension to be an alternative choice. This study aims to determine the effectiveness of non-pharmacological therapy in hypertensive patients in reducing and controlling normal blood pressure. The study used a literature review method with data sources of international scientific journals and articles using the PubMed database. The information search strategy used a combination of keywords such as "non-pharmacological therapy for hypertension" and "the effectiveness of non-pharmacological therapy in hypertension". Through the database search, 190 scientific articles and journals were obtained. A total of 12 scientific journals and articles were selected as reference sources for research that met the criteria. The results obtained from 12 journals and scientific articles showed that non-pharmacological therapy for hypertension was effective in reducing systolic and diastolic blood pressure. Non-pharmacological therapies recommended according to the reference sources are lifestyle modification, increasing physical activity such as aerobic exercise, intake of low sodium salt, acupuncture therapy, listening to music, relaxation therapy and increasing compliance with therapeutic interventions.


Abou-Saleh H, Pathan AR, Daalis A, Hubrack S, Abou-Jassoum H, Al-Naeimi H, et al. Inositol 1,4,5-trisphosphate (IP3) receptor up-regulation in hypertension is associated with sensitization of Ca2+ release and vascular smooth muscle contractility. J Biol Chem. 2013; 288(46):32941–51.

Ballut OM, Alzahrani AA, Alzahrani RA, et al. The Impact of Non-pharmacological Interventions on Blood Pressure Control in Patients With Hypertension: A Systematic Review. Cureus. 2023; 15(11).

Cao L, Li X, Yan P, et al. The effectiveness of aerobic exercise for hypertensive population: A systematic review and meta-analysis. J Clin Hypertens (Greenwich). 2019;21(7):868-876.

Carey RM, Muntner P, Bosworth HB, Whelton PK. Prevention and Control of Hypertension: JACC Health Promotion Series. J Am Coll Cardiol. 2018;72(11):1278-1293.

Castellano TC. Non-Pharmacological Interventions for the Management of Chronic Health Conditions and Non-Communicable Diseases. Int J Environ Res Public Health. 2022;19(14):8536.

Croze ML, Soulage CO. Potential role and therapeutic interests of myo-inositol in metabolic diseases. Biochimie. 2013; 95(10):1811–27

Gabiola J, Morales D, Quizon O, et al. The EffectiveNess of LIfestyle with Diet and Physical Activity Education Program Among Prehypertensives and Stage 1 Hypertensives in an Urban Community Setting (ENLIGHTEN) Study. J Community Health. 2020; 45(3):478-487

Iqbal AM, Jamal SF. Essential Hypertension. Treasure Island (FL): StatPearls Publishing; 2023.

Kementerian Kesehatan RI. Hasil Utama RISKESDAS 2018; 2018.

Khalil H, Zeltser R. Antihypertensive Medications. [Updated 2023 May 8]. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2024 Jan-. Available from: https://www.ncbi.nlm.nih.gov/books/NBK554579/

Khandekar JS, Vasavi VL, Singh VP, Samuel SR, Sudhan SG, Khandelwal B. Effect of Yoga on Blood Pressure in Prehypertension: A Systematic Review and Meta-Analysis. ScientificWorldJournal. 2021

Kotruchin P, Imoun S, Mitsungnern T, et al. The effects of foot reflexology on blood pressure and heart rate: A randomized clinical trial in stage-2 hypertensive patients. J Clin Hypertens (Greenwich). 2021;23(3):680-686.

Kühlmann AY, Etnel JR, Roos HJW, et al. Systematic review and meta-analysis of music interventions in hypertension treatment: a quest for answers. BMC Cardiovasc Disord. 2016;16:69

Liao IC, Chen SL, Wang MY, Tsai PS. Effects of Massage on Blood Pressure in Patients With Hypertension and Prehypertension: A Meta-analysis of Randomized Controlled Trials. J Cardiovasc Nurs. 2016 Jan-Feb;31(1):73-83.

Mills KT et al. Global Disparities of Hypertension Prevalence and Control: A Systematic Analysis of Population-Based Studies From 90 Countries. Circulation. 2016;134, 441–450

Mills KT, Stefanescu A, He J. The global epidemiology of hypertension. Nat Rev Nephrol. 2020;16(4):223-237.

Palmer M, Sutherland J, Barnard S, et al. The effectiveness of smoking cessation, physical activity/diet and alcohol reduction interventions delivered by mobile phones for the prevention of non-communicable diseases: A systematic review of randomised controlled trials. PLoS One. 2018;13(1).

Shao T, Liang L, Zhou C, et al. Short-term efficacy of non-pharmacological interventions for global population with elevated blood pressure: A network meta-analysis. Front Public Health. 2023; 10:1051581.

Sutoo D, Akiyama K. Music improves dopaminergic neurotransmission: demonstration based on the effect of music on blood pressure regulation. Brain Res. 2004;1016(2):255–62.

Syifa AZ. Efektivitas Terapi Bekam Pada Penderita Hipertensi : Studi Literatur Nursing Information Journal. 2021;1 (Issue 1)

Wang J, Xiong X. Evidence‐based Chinese medicine for hypertension. Evid Based Complement Alternat Med. 2013;2013:978398

Wang T, Li H, Feng S, et al. Efficacy of acupuncture for hypertension in the elderly: a systematic review and meta-analysis. Front Cardiovasc Med. 2023;10:1147135.

Wen H, Wang L. Reducing effect of aerobic exercise on blood pressure of essential hypertensive patients: A meta-analysis. Medicine (Baltimore). 2017; 96(11).

WHO. Hypertension [Internet]; 2023 [disitasi tanggal 09 januari 2023].

Williamson W, Foster C, Reid H, Kelly P, Lewandowski AJ, Boardman H, Roberts N, McCartney D, Huckstep O, Newton J, Dawes H, Gerry S, Leeson P. Will Exercise Advice Be Sufficient for Treatment of Young Adults With Prehypertension and Hypertension? A Systematic Review and Meta-Analysis. Hypertension. 2016 Jul;68(1):78-87

Zhou B et al. Worldwide trends in blood pressure from 1975 to 2015: a pooled analysis of 1479 population-based measurement studies with 19·1 million participants. Lancet 2017; 389, 37–55

Zhao X, Yin X, Li X, et al. Using a low-sodium, high-potassium salt substitute to reduce blood pressure among Tibetans with high blood pressure: a patient-blinded randomized controlled trial. PLoS One. 2014;9(10)



How to Cite

Nadiya Widda Mawaddah, Damayanti, E., & Pardilawati, C. Y. . (2024). Effectiveness of Non-Pharmacologic Therapy in Hypertensive Patients. Medical Profession Journal of Lampung, 14(3), 613-616. https://doi.org/10.53089/medula.v14i3.1056




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