Aspects of Laboratory Examination in Pneumonia Patients

Authors

  • Dinul Aliya Julianti Medical Faculty, Lampung University
  • Putu Ristyaning Ayu Sangging
  • Citra Yuliyanda Pardilawati

DOI:

https://doi.org/10.53089/medula.v13i2.579

Keywords:

Diagnosis, laboratory examination, pneumonia

Abstract

Pneumonia is one of the lower respiratory tract diseases with the most deaths in the world. Pneumonia is an inflammatory disease of the pulmonary parenchyma caused by microorganisms such as bacteria, viruses, or fungi. Pneumonia is classified based on the environment and the way it is obtained, with the most cases being Community-acquired pneumonia (CAP). The discovery of pneumonia cases in Indonesia has not met the national target and is still the main problem causing the largest cause of death in toddlers. Thus, the establishment of an immediate diagnosis becomes very important in order to prevent the occurrence of aggravation in pneumonia patients. The diagnosis begins with an anamnesis that contains the patient's disease history, physical examination, and supporting examination. These supporting examinations include laboratory examinations such as routine blood tests, Gram staining and culture on blood specimens and sputum, inflammatory biomarker examinations (Procalcitonin, C-Reactive Protein, and Interleukin-6), blood gas analysis (AGD), and PCR (Polymerase Chain Reaction) tests. Each of these tests has different values of sensitivity and diagnostic specificity. The selection of laboratory examinations in each health service facility tends to be non-specific, so it needs to be adjusted between its availability while still considering the value of sensitivity and specificity so that the examination is more effective and efficient.

References

Kemenkes RI. Profil Kesehatan Indonesia 2021 [Internet]. Sibuea F, Hardhana B, Widiantini W, editors. Pusdatin.Kemenkes.Go.Id. Jakarta: Kementerian Kesehatan Republik Indonesia Jalan; 2022. 182–4 p. Available from: http://www.kemkes/go.id

Cilloniz C, Martin-Loeches I, Garcia-Vidal C, Jose AS, Torres A. Microbial etiology of pneumonia: Epidemiology, diagnosis and resistance patterns. Int J Mol Sci [Internet]. 2016;17(12). Available from: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5187920/pdf/ijms-17-02120.pdf

Vernet G, Saha S, Satzke C, Burgess DH, Alderson M, Maisonneuve JF, et al. Laboratory-based diagnosis of pneumococcal pneumonia: state of the art and unmet needs. Clin Microbiol Infect [Internet]. 2011;17(3):1–13. Available from: http://dx.doi.org/10.1111/j.1469-0691.2011.03496.x

Karakioulaki M, Stolz D. Biomarkers in Pneumonia-Beyond Procalcitonin. Int J Mol Sci [Internet]. 2019;20(8):1–18. Available from: https://www.researchgate.net/publication/332634948_Biomarkers_in_Pneumonia-Beyond_Procalcitonin

Torres A, Cilloniz C, Niederman MS, Menéndez R, Chalmers JD, Wunderink RG, et al. Pneumonia. Nat Rev Dis Prim [Internet]. 2021;7(1):7–10. Available from: www.nature.com/nrdp

Dahlan Z. Pneumonia. In: Setiati S, Alwi I, Sudoyo AW, Setiyohadi M, ari Fahrial syam, editors. Buku Ajar Ilmu Penyakit Dalam Jilid 2. 6th ed. Jakarta: Interna Publishing; 2014. p. 1608–19.

Suci LN. Pendekatan diagnosis dan tatalaksana pneumonia pada anak. J Kedokt Nanggroe Med. 2020;3(1):30–8.

Arlini, Yunita. Diagnosis Community Aquired Pneumonia (CAP) dan Tatalaksana Terkini. In: Bagian Pulmunologi dan Kedokteran Respirasi Fakultas Kedokteran Universitas Syiah Kuala. Banda Aceh: Universitas Syiah Kuala; 2015. p. 86–97.

Metlay JP, Waterer GW, Long AC, Anzueto A, Brozek J, Crothers K, et al. Diagnosis and treatment of adults with community-acquired pneumonia. Am J Respir Crit Care Med. 2019;200(7):E45–67.

Huang Y, Liu A, Liang L, Jiang J, Luo H, Deng W, et al. Diagnostic value of blood parameters for community-acquired pneumonia. Int Immunopharmacol [Internet]. 2018;64(August):10–5. Available from: https://doi.org/10.1016/j.intimp.2018.08.022

Del Rio-Pertuz G, Gutiérrez JF, Triana AJ, Molinares JL, Robledo-Solano AB, Meza JL, et al. Usefulness of sputum gram stain for etiologic diagnosis in community-acquired pneumonia: A systematic review and meta-analysis. BMC Infect Dis. 2019;19(1):1–12.

Zhang D, Danny Y, Makam AN. Utility of Blood Cultures in Pneumonia. Am J Med. 2019;132(10):1233–8.

Cham G, Yan S, Heng BH, Seow E. Predicting positive blood cultures in patients presenting with pneumonia at an Emergency Department in Singapore. Ann Acad Med Singapore. 2016;38(6):508–14.

Hunton R. Updated concepts in the diagnosis and management of community-Acquired pneumonia. J Am Acad Physician Assist. 2019;32(10):18–23.

Keramat F, Basir HRG, Abdoli E, Aghdam AS, Poorolajal J. Association of serum procalcitonin and C-reactive protein levels with CURB-65 criteria among patients with community-acquired pneumonia. Int J Gen Med. 2018;11:217–23.

Andrijevic I, Matijasevic J, Andrijevic L, Kovacevic T, Zaric B. Interleukin-6 and procalcitonin as biomarkers in mortality prediction of hospitalized patients with community acquired pneumonia. Ann Thorac Med [Internet]. 2014;9(3):162–7. Available from: www.thoracicmedicine.org

Gattinoni L, Pesenti A, Matthay M. Understanding blood gas analysis. Intensive Care Med. 2018;44(1):91–3.

Castro D, Patil SM, Keenaghan M. Arterial Blood Gas. [Updated 2022 Sep 12]. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2022 Jan-. Available from: https://www.ncbi.nlm.nih.gov/books/NBK536919/

Published

2023-02-17

How to Cite

Julianti, D. A. ., Sangging, P. R. A., & Pardilawati, C. Y. (2023). Aspects of Laboratory Examination in Pneumonia Patients. Medical Profession Journal of Lampung, 13(2), 147-152. https://doi.org/10.53089/medula.v13i2.579

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