The Effect Of Giving Bitter Melon Extract (Momordica Charantia L) And Used Cooking Oil On Coronary Artery : Literature Review
DOI:
https://doi.org/10.53089/medula.v14i10.1392Keywords:
coronary artery, atherosclerosis, bitter melon extract, used cooking oilAbstract
Coronary heart disease is one of the main causes of death in the world, with more than 17 million deaths every year due to heart and blood vessel diseases, with around 8.7 million of them caused by coronary heart disease and around 15 out of 1000 residents in Indonesia which is equivalent to around 2,78,064 people suffer from coronary heart disease. The high frequency of use of cooking oil means that cooking oil is often used repeatedly. Repeated use of cooking oil can cause damage to various body organs such as the liver, heart, kidneys and arteries. Exposure to free radicals and free fatty acids obtained from used cooking oil if it enters the body will result in oxidative stress. The atherosclerosis process is characterized by the change of k-LDL to Ox-LDL which triggers endothelial dysfunction and the formation of atherosclerotic plaque on the walls of blood vessels. The high fatty acid content in used cooking oil can easily stick to the walls of blood vessels, so that it will accumulate and form atherosclerotic plaque. One of the alternative antioxidants that comes from herbs is bitter melon (Momordica Charantia L). Bitter melon contains flavonoid compounds. Flavonoids are secondary metabolites which are antioxidants that can inhibit free radical activity and can prevent atherosclerosis. Antioxidant compounds can reduce atherosclerosis by inhibiting LDL metabolism in secondary atherosclerotic lesions to prevent LDL oxidation in these lesions.
References
World Health Organization. Cardiovascular Diseases [Internet]. 2021 [cited 2023 Jun 3]. Available from: https://www.who.int/health-topics/cardiovascular-diseases
Kementerian Kesehatan Republik Indonesia. Hari Jantung Sedunia (World Heart Day) [Internet]. 2019 [cited 2023 Jun 3]. Available from: https://p2ptm.kemkes.go.id/kegiatan-p2ptm/pusat-/hari-jantung-sedunia-world-heart-day-your-heart-is-our-heart-too
American Heart Association. Coronary Artery Disease-Coronary Heart Disease. Dallas: American Heart Association; [year unavailable].
Nurtamin T. Potensi curcumin untuk mencegah aterosklerosis. Cermin Dunia Kedokteran. 2014;41(8):400-536.
Hajar EWI, Purba AFW, Handayani P, Mardiah. Proses pemurnian minyak jelantah menggunakan ampas tebu untuk pembuatan sabun padat. J Integr Proses. 2016;6(2):57–63.
Susianti. Pemberian minyak jelantah yang diekstrak dengan buah mengkudu (Morinda citrifolia) terhadap kerusakan hati. Maj Kedokteran Andalas. 2014;37(2):54–60.
Nurfadilah LD, Nurainiwati SA, Agustini SM. Pengaruh pemberian minyak deep frying terhadap perubahan histopatologi jantung tikus putih (Rattus novergicus strain Wistar). Saintika Medika. 2013;9(1):54–58.
Raynaldo LM. Potential of Pare (Momordica charantia L.) as a lowering level blood cholesterol. J Ilm Kesehatan Sandi Husada. 2019;10(2):188–192.
Aziz M, Yadav K. Pathogenesis of atherosclerosis: A review. Med Clin Rev. 2016;2(3):2.
Sargowo D. Pathogenesis aterosklerosis. Malang: Universitas Brawijaya Press; 2015. p. 45-57.
Adi PR. Pencegahan dan penatalaksanaan aterosklerosis. In: Setiati S, Alwi I, Sudoyo AW, editors. Buku Ajar Ilmu Penyakit Dalam. Vol. II. 6th ed. Jakarta: Interna Publishing; 2014.
Abbas AK, Aster JC, Kumar V. Buku Ajar Patologi Robbins. 9th ed. Singapura: Elsevier Saunders; 2015.
Muhartono, Yudistira MA, Putri NT, Sari TN, Oktafany. Minyak jelantah menyebabkan kerusakan pada arteri koronaria, miokardium, dan hepar tikus putih (Rattus norvegicus) jantan galur Sprague Dawley. J Kedokteran Univ Lampung. 2018;2(2):129–135.
Leong XF, Ng CY, Jaarin K, Mustafa MR. Effects of repeated heating of cooking oils on antioxidant content and endothelial function. Austin J Pharmacol Ther. 2015;3(2):10-68.
Andiani A, Harsa MS. Effect administration of ethanol extract of bitter melon (Momordica charantia L.) on the reduction of MDA (Malondialdehyde) levels serum in rats given a high-fat diet. J Ilm Kedokteran Wijaya Kusuma. 2018;7(2):196.
Syadza MN, Isnawati M. Pengaruh pemberian jus pare (Momordica charantia Linn.) dan jus jeruk nipis (Citrus aurantifolia) terhadap peningkatan kadar kolesterol HDL (High Density Lipoprotein) tikus Sprague Dawley dislipidemia. J Nutr Coll. 2014;3(4):933–942.
Rizeki MF, Fatmawati H, Wulandari P. Efek pemberian ekstrak buah pare (Momordica charantia) terhadap kadar NF-kB (Nuclear Factor Kappa Beta) pada tikus Wistar (Rattus norvegicus) yang diberi diet aterogenik. Art Ilm Has Penelit Mahasiswa. 2012.
Downloads
Published
How to Cite
Issue
Section
License
Copyright (c) 2025 Medical Profession Journal of Lampung
This work is licensed under a Creative Commons Attribution-ShareAlike 4.0 International License.
