The Potential of Beetroots (Beta vulgaris L.) as Nephroprotector from Kidney Damage due to Free Radicals


  • Nabila Shafira
  • Putu Ristyaning Ayu
  • Susianti



antioxidant, Beta vulgaris L, nephroprotector


Every human being is born with a pair of kidneys located retroperitoneal in the body cavity. Kidney is an organ that filters blood and gets rid of the body’s metabolic waste. In addition, kidneys also play an important role in the excretion of drugs from the body, thus making it vulnerable to damage due to drugs and free radicals. in small amounts, free radicals can be converted into a non-toxic compound through the defence mechanism of endogenous antioxidants. However, when exposed to large amounts of free radicals, there will be an imbalance between the antioxidants produced and the antioxidants needed by the body. Overtime, the body will run out of antioxidants and free radicals will accumulate in the body. These free radicals wil form a covalent bond with the cell in the body especially in the proximal convoluted tubules of the kidneys and cause damage to the kidneys. This mechanism is called oxidative stress. Decreased kidney function can be assessed through blood urea and creatinine examination. Beetroot (Beta vulgaris L.) is a root plant that is generally used as vegetables. Beetroot is one of vegetables with the highest antioxidants content. Several studies have shown that beetroot extract has activity as a nephroprotector due to its abundant exogenous antioxidant contents. The antioxidant that are found in beetroots are flavonoids, betacyanins, betaxantins, ascorbic acidz, and carotenoids.


Hall JE. Guyton and hall textbook of medical physiology (Edisi 13). Mississipi: Elsevier; 2016

Pusdatin Kemkes RI. Infodatin: Situasi Penyakit Ginjal Kronis. Jakarta: Pusdatin Kemkes; 2017

Verdiansah. Pemeriksaan Fungsi Ginjal. CDK 237. 2016;42(2): 148-154.

Werdhasari A. Peran antioksidan bagi kesehatan. J. Bio. Med. Ind. 2014;3(2):59-68

El Gamal AA, Al Said MS, Raish M, Al-Sohaibani, Al-Massarani SM, Ahmad A, dkk. Beetroot (beta vulgaris l.) extract ameliorates gentamicin induced nephrotoxicity associated oxidative stress, inflammation, and apoptosis in rodent model. Hindawi Publishing Coorporation. 2014;1-12

Sarfaraz S. Ikram R. Evaluation of nephroprotective effect of beta vulgaris at different doses. Pak. J. Pharm. Sci. 2019;36(1):9-13

Bari MAMA, Albadri HMB. Hussein HF. The protective effect of beetroot against dexamethasone induced damage in liver, kidney and hyperlipidemic effects in mice. World. J. Pharm. Med. Res. 2018; 4(11): 60-68

Amoghimath S, Majagi SI. Drug induced kidney disease. Open. Acc. J. Toxicol. 2017;2(1):1-3.

International Society of Nephrology. Kidney disease: improving global outcomes (KDIGO) clinical practice guideline for acute kidney injury. Boston: International Society of Nephrology; 2012

Silverthorn DU, Jhonson BR, Ober WC, Garisson CW, Silverthorn AC. Fisiologi manusia: sebuah pendekatan terintegrasi (Edisi 6). Jakarta: EGC; 2012

Tortora GJ, Derrickson B. Principles of anatomy and physiology (Edisi 14). Danvers: John Wiley and Sons inc; 2014

Wijaya H, Junaidi L. Antioksidan: mekanisme kerja dan fungsinya dalam tubuh manusia. J. Agro.Based. Industry. 2011; 28(2): 44-55

Mazer M, Perrone J. Acetaminophen-induced nephrotoxicity: pathophysiology, clinical manifestation, and management. J. Med. Toxicol. 2018; 4(1):1-5.

Splittstoesser WE. Vegetable growing handbook. Van Nostrand Rainhold Company: New York; 1984

Navazio. John. Colley. Micaela. Zyskowski. Principles and practices of organic beet seed production in the pacific northwest. Port Townsend: Organic seed alliance; 2010

Straus S. Bavec F. Turinek M. Slatnar A. Rozman C. Bavec M. Nutritional value and economic feasibility of red beetroot (beta vulgaris l. ssp. Vulgaris rote kugel) from different production systems. Afr. J. Agric. Res. 2012; 7(42)5653-60

Baiao DS. Silva DVT. Aguila EMD. Paschoalin VMF. Nutritional, bioactive and physicochemical characteristics of different beetroot formulations; 2017

Sari NMI. Hudha AM. Prihanta W. Uji kadar betasianin pada kulit bit (beta vulgaris L.) dengan pelarut etanol dan pengembangannya sebagai sumber belajar biologi. J. Pend. Bio. Ind. 2016; 2(1): 72-77

Mazer M. Perrone J. Acetaminophen-induced nephrotoxicity: pathophysiology, clinical manifestation, and management. J. Med. Toxicol. 2008;4(1):1-5




How to Cite

Nabila Shafira, Putu Ristyaning Ayu, & Susianti. (2019). The Potential of Beetroots (Beta vulgaris L.) as Nephroprotector from Kidney Damage due to Free Radicals. Medical Profession Journal of Lampung, 9(2), 322-327.




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