Effect of Tomato Juice (Solanum lycopersicum) on The Thickness of Seminiferous Epithelium of White Rats Sprague dawley Strain Induced by Gentamicin
Keywords:Gentamicin, Lycopene, Epithelium Thickness
Aminoglycosides including gentamicin have been used successfully for decades in the treatment of gram-negative bacterial infections. However, gentamicin produces testicular toxicity, resulting in limited therapeutic doses. Lycopene, one of the antioxidants in tomatoes, has singlet-oxygen and free radical scavenging capacity. Moreover, lycopene serves as a promising intervention for testicular toxicity associated with oxidative stress. Researchers wanted to see the effect of tomato juice on the seminiferous tubules of white rats. This type of research is experimental research with post test only control group design. The rats used were 29 male white rats (Rattus novergicus) which were divided into 5 groups, namely the negative control group as normal control. The positive control group was given gentamicin 20 mg/kgBW. Treatment groups 1, 2, and 3 were the treatment groups with gentamicin 20 mg/kgBW and tomato juice 25%, 50%, and 100%. Gentamicin was given for 10 days and tomato juice was given for 24 days. Data analysis was carried out using the One Way Annova method and continued with Post Hoc. After statistical testing, there was a significant effect of giving tomato juice on seminiferous epithelial thickness induced by gentamicin in white rats of the Sprague Dawley strain (p<0.05).
Zahedi A, Fathiazad F, Khaki A, Ahmadnejad B. Protective effect of ginger on gentamicin-induced apoptosis in testis of rats. Adv Pharm Bull. 2012;2(2):197-200. . 2009;3(4):105-109.
Kailaku SI, K. T. Dewandari, Sunarmani. Potensi likopen dalam tomat untuk kesehatan. Bul Teknol Pascapanen Pertan. 2007;3:50-58.
Aly HAA. Testicular toxicity of gentamicin in adult rats: Ameliorative effect of lycopene. Hum Exp Toxicol. 2019;38(11):1302-1313.
Ateşşahin A, ürk GT, Karahan I, Yilmaz S, Çeribaşi AO, Bulmuş Ö. Lycopene prevents adriamycin-induced testicular toxicity in rats. Fertil Steril. 2006;85 (1):1216-1222.
Dahlan, S.2014.Statistik Untuk Kedokteran Dan Kesehatan. 6th edn. Jakarta: Salemba Medika
Khaki A, Novin MG, Khaki AA, Nouri M. 1683-1689.Pdf. J Biol Sci. 2008;11(13):1683-1684.
El-maddawy ZK. Modulation of Gentamicin-induced Testicular and Brain Damage in Rats. 2014;8(3):284-293.
Narayana K. An aminoglycoside antibiotic gentamycin induces oxidative stress, reduces antioxidant reserve and impairs spermatogenesis in rats. J Toxicol Sci. 2008;33(1):85-96.
Al-Damegh MA. Stress-Induced Changes in Testosterone Secretion in Male Rats: Role of Oxidative Stress and Modulation by Antioxidants. Open J Anim Sci. 2014;04(02):70-78.
Cholifah S, Arsyad, Salni. Pengaruh Pemberian Ekstrak Pare ( Momordica Charantia , L ) Terhadap Struktur Histologi Testis dan Epididimis Tikus Jantan. MKS, Th 46. 2014;(2):149-157.
Kulhan N, Kulhan M, Turkler C, et al. Effect of lycopene on oxidative ovarian damage induced by cisplatin in rats. Gen Physiol Biophys. 2019;38(4):253-258.
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