The Effect of Vitamin C in Pyramidal Cell Count of CA1 Layer of The Hippocampus on Male Albino Rat (Rattus norvegicus) Sprague Dawley Strain Induced by Monosodium Glutamate (MSG)


  • Shinta Melia Desiana Lampung University
  • Susianti Susianti Universitas Lampung
  • Anggraeni Janar Wulan Universitas Lampung



CA1 layer, hippocampus, MSG, pyramidal cell, vitamin C


Excessive consumption of MSG leads to decrease of the pyramidal cell of the CA1 layer of the hippocampus. Toxic level of glutamate causes overstimulation of glutamate receptor which leads to pyramidal cell death, thus results in decrease of pyramidal cell in CA1 layer of the hippocampus. Vitamin C as a strong antioxidant is expected to protect the oxidative damage in hippocampus caused by MSG induction. The aim of this research is to know the effect of vitamin C in pyramidal cell count of the CA1 layer of the hippocampus on male albino rat induced by MSG. This study is an experimental with Post Test Only Control Group contains of 30 rats divided into 5 groups which are, negative control (given aquadest), positive control (given MSG 4 g/kgBB), treatment 1 (given MSG 4 g/kgBB and vitamin C 100 mg/kgBB), treatment 2 (given MSG 4 g/kgBB and vitamin C 200 mg/kgBB) and treatment 3 (given MSG 4 g/kgBB and vitamin C 400 mg/kgBB) for 21 days. The measurement was done by using imageJ program in five microscopic field of five slices of the hippocampal CA1 layer. The analysis of vitamin C in pyramidal cell count of CA1 layer of hippocampus shows that there is significant difference (p=0,00). Vitamin C alter the decrease of CA1 hippocampal pyramidal cell of male albino rat induced by MSG.


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How to Cite

Shinta Melia Desiana, Susianti, S., & Wulan, A. J. (2023). The Effect of Vitamin C in Pyramidal Cell Count of CA1 Layer of The Hippocampus on Male Albino Rat (Rattus norvegicus) Sprague Dawley Strain Induced by Monosodium Glutamate (MSG). Medical Profession Journal of Lampung, 13(5), 816-826.




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