Inhibition Test Of Sulfur Solutio Against The Growth Of Propionibacterium acnes Bacteria by In Vitro ways
DOI:
https://doi.org/10.53089/medula.v10i3.97Keywords:
Acne Vulgaris, propionibacterium acne, sulfurAbstract
Acne Vulgaris is an inflammation of the polysebaseal follicles indicated by the appearance of blackheads, papules, pustules, cysts and nodules, which often occur mainly in the chest (15%), face (99%), and back (60%). In Indonesia around 95-100% of men and 83-85% of women aged 16-17 years suffer from acne. One of the microorganisms that cause acne vulgaris is Propionibacterium acnes bacteria which is a normal flora on the skin. In treatment, acne vulgaris wide-spectrum antibiotics have been commonly used as a treatment for acne, as the time goes by, it has been found there are increasement of Propionibacterium acnes resistance to antibiotics like erythromycin, clindamycin, and tetracycline. Sulfur has been widely used in anti-acne products which have an antibacterial function and can inhibit the growth of Propionibacterium acne as a cause of acne. This study aims to test sulfur solutio with concentrations that are often used in anti-acne products, namely 2-10% in inhibiting P.acne bacteria. This type of research is an experimental laboratory with a well method. Solutio sulfur is divided by various concentrations of 10%, 8%, 6%, 4%, and 2%, with K (-) is distilled water, and K (+) is a clindamycin gel antibiotic. The data is based on the results of the measurement of the inhibition zone formed and tested with One Way Anova. The results of this study indicate the diameter of the inhibition zone formed sequentially, namely: 12.70 mm, 10.55 mm, 7.70 mm, 5.80 mm, 4.67 mm, positive control of 30,075 mm and negative concentration of 0 mm (p value = 0,001). There is an antibacterial effect of sulfur solutio with a concentration of 10%, 8%, 6%, 4% and 2% against Propionibacterium acnes bacteria.
References
Tan JKL, Bhate K. A Global Perspective on the Epidemiology of Acne.British Journal of Dermatology. 2014; 172(S1): 3–12.
Afriyanti RN. Akne Vulgaris Pada Remaja.Medical Faculty of Lampung University. 2015; 4(6):102–109.
Sitohang IBS, Wasitatmadja SM .Ilmu Penyakit Kulit dan Kelamin7th ed. Jakarta: Universitas Indonesia; 2016.
Begatin, E., Guadanhim, L.R., terzian, L.R., florez, M. Acne Vulgaris: Prevalence and Clinical Forms in Adolescents from Sao Paulo, Brazil. Sao Paulo. An Braz Dermatol; 2014.
Behzadi E, Behzadi P, Voicu C. Propionibacterium acnes and the Skin Disease of Acne Vulgaris.RoJCED. 2016; 3(2):117–120.
Agustina R., Annisa P., Anisah F. Uji Daya Hambat Ekstrak Etanol Daun Ungu (Graptophyllum pictum(L) GRIFF)) Terhadap Bakteri Staphylococcus epidermidis dan Bakteri Propionibacterium acnes Penyebab Jerawat dengan Metode Cakram. 2019; 4(1): 1-9
Ruth, C.S. Efektifitas Kombinasi Triclosan, Asam Salisilat, Sulfur Dalam Beberapa Produk Bedak Antiacne Terhadap Pertumbuhan Propionibacterium acnes. Fakultas Kedokteran Universitas Sumatera Utara; 2012
Irwana., Arif. Perbandingan Sabun Sulfur 2-4% dengan sabun Sulfur 10% sebagai Pengobatan Skabies. Skripsi. Jakarta : Fakultas Kedokteran Uin syarif Hidayatullah; 2015.
Majestha RP., Puguh Riyanto. 2016. Pengaruh Pemakaian Sabun Sulfur Terhadap Jumlah Lesi Akne Vulgaris: Penelitian Klinis pada Mahasiswa Penderita Akne Vulgaris Yang Diberi Terapi Standar Tretinoin 0,025% + TSF 15. Skripsi. Semarang: Fakultas Kedokteran Universitas Diponegoro; 2016
Yasmine S., Julia L., Novitarasari I., Prasetia S. 2016. Sulfur sebagai unsur dan komponen dalam kehidupan.Semarang: Akademi Farmasi Theresiana; 2016.
Downloads
Published
How to Cite
Issue
Section
License
Copyright (c) 2020 MEDULA
This work is licensed under a Creative Commons Attribution-ShareAlike 4.0 International License.