Role of Glycated Albumin in Glycemic Control and Diagnosis of Diabetes Mellitus


  • Sharlene Sabrina
  • Putu Ristyaning Ayu
  • Iswandi Darwis



Diabetes Mellitus, glycated albumin, glycemic control, hba1c


Diabetes Mellitus or DM is a chronic metabolic syndrome, which is usually characterized by excess glycemic conditions or hyperglycemia. The incidence of diabetes is increasing rapidly in populations in Asia, especially in countries with fairly fast economic growth. At present, there are around 171-194 million people in the world who suffer from diabetes. Fructosamine, glycated albumin and HbA1c are glycate proteins used to evaluate glycemic control in diabetic patients. Albumin glycate (GA) has a much shorter half-life than erythrocytes, so glycemic albumin can reflect glycemic control on a short-term basis (around 2-3 weeks) compared to HbA1c. In addition, GA has faster and greater changes compared to HbA1c, so GA may be more useful for describing glycemic control. The concentration of albumin glycate can be determined in several ways, namely by using the colorimetric method with thiobarbituric acid, the enzymatic method with proteinase and ketamine oxidase, the HPLC chromatography method, and the mass spectrometry method. Several studies have concluded that there is a strong relationship between glycated albumin, HbA1c and fasting blood glucose so that glycated albumin can be used as a glycemic control tool for early detection of diabetes complications, aiding diagnosis of diabetes and assisting in the selection of adequate management for diabetes  patients.


Ake A. Saraswati MR, Widiana IGR. Glycated Albumin Sebagai Penanda Kontrol Glikemik Pada Penderita Diabetes Melitus Tipe 2. Udayana Journal of Internal Medicine. Udayana University, Bali. 2017. 1(1):1-7

Simanjuntak S, Darmanta B, Kartikasari EY, Reza F. Hubungan Glycated Albumin Dengan HbA1c Pada Pasien Diabetes Mellitus Tipe II. Jurnal Kedokteran Methodist. Universitas Methodist Indonesia. 2017. 9(9).

Immanuel S. Peran Pemeriksaan Albumin Glikat Dalam Penatalaksanaan Diabetes Mellitus. Departemen Patologi Klinik FKUI-RSCM.

Sayed ZHE, Ismail SM, El-hagrasy HA. Glycated Albumin as a Predictor of Glycemic State in Type 2 Diabetes Mellitus with Chronic Kidney Disease. International Journal of Diabetes Research. 2018. 7(3): 50-56.

Yazdanpanah S, Rabiee M, Tahriri M, Abdolrahim M, Rajab A, Jazayeri H., et al. Evaluation of Glycated Albumin (GA) and GA/HbA1c Ratio For Diagnosis of Diabetes and Glycemic Control: A Comprehensive Review. Critical Reviews in Clinical Laboratory Sciences. 2017. 54(4): 214-232.

Wu WC, Ma WY, Wei JN, Yu WY, Lin MS, Shih SR., et al. Serum Glycated Albumin to Guide the Diagnosis of Diabetes Mellitus. Journal PLOS One. 2016. 11(1).

Dozio E, Gaetano ND, Findeisen P, Romanelli MMC. Glycated Albumin: From Biochemistry and Laboratory Medicine to Clinical Practice. Springer Science and Business Media New York. 2016.

Freitas PAC, Ehlert LR, Camargo JL. Glycated Albumin: A Potential Biomarker in Diabetes. Arch Endocrinol Metab. 2017. 61(3):296-304

Furushyo N, Hayashi J. Glycated Albumin and Diabetes Mellitus. Biochimica et Biophysica Acta Elsevier. 2013.

Ikezaki H, Furusyo N, Ihara T, Hayashi T, Ura K, Hiramine S., et al. Glycated Albumin As a Diagnostic Tool For Diabetes iIn a General Japanese Population. Metabolism Clinical and Experimental Journal Elsevier. 2015.

Koga M, Kasayama S. Clinical Impact of Glycated Albumin as another Glycemic Control Marker. Endocrine Journal of The Japan Endocrine Society. 2010. 57(9): 751-762

Widyadi ED, Nugraha J, Marpaung FR. Glycated Albumin and HbA1c in Diabetic Nephropathy. Indonesian Journal of Clinical Pathology and Medical Laboratory. 2016. 22(3):258-262.



How to Cite

Sharlene Sabrina, Putu Ristyaning Ayu, & Iswandi Darwis. (2019). Role of Glycated Albumin in Glycemic Control and Diagnosis of Diabetes Mellitus. Medical Profession Journal of Lampung, 9(2), 385-389.




Most read articles by the same author(s)

<< < 1 2 3 4 > >>