COVID-19 in Pregnancy: Is it dangerous?


  • Hanifa Salma Ramadhani
  • Nurul Islamy
  • Ade Yonata



Coronavirus, fetus, intra-uterine, pregnancy


Coronavirus disease 2019 (COVID-19) is caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) which spread rapidly throughout the world. These health emergencies, especially deadly in vulnerable populations and communities where health care providers are not adequately prepared to manage this infection. Pregnant women and fetuses represent high-risk populations in this pandemic. Study this article compiled using the literature review method, derived from journals and books resulting from literature searching from search engines (Google and Google Scholar) and electronic source of database (PubMed). There are 37 references reviewed in this article review. A challenge in treating pregnant patients affected by SARS-CoV-2. The explanation in the review of this article is to present a discussion of COVID-19 in pregnancy, intrauterine transmission, and fetal complications in the mother. Fetal health is something that must be taken into consideration during labor In addition, it needs to be focused on the safety of health workers in treating COVID-19 patients. COVID-19 in pregnancy is dangerous for mothers and infants, mothers with COVID-19 have clinical airway symptoms that will aggravate the state of pregnancy, for infants if intrauterine transmission occurs, COVID-19 in infants will cause ARDS (acute respiratory distress syndrome) so endangering lives. The clinical characteristics of pregnant women with COVID-19 are similar to non-pregnant adults. Fetal and neonatal outcomes appear to be good in some cases, but available data only cover pregnant women infected in the third trimester.


McIntosh K. Coronavirus disease 2019 (COVID-19) [Internet]. UpToDate. 2020 [diakses tanggal 11 Juni 2020]. p. 1–27. Tersedia di:

Qiao J. What are the risks of COVID-19 infection in pregnant women? Lancet. 2020;395(10226):760–2.

World Health Organization. Coronavirus disease COVID-2019. Vol. 142, WHO. Geneva; 2020.

Yu A, Wang Z, Ren W, Wu Z, Hu Z, Li L, et al. Epidemic analysis of COVID-19 in China after Wuhan was restricted. Res Sq. 2020;1:1–14.

Sun K, Chen J, Viboud C. Early epidemiological analysis of the coronavirus disease 2019 outbreak based on crowdsourced data: a population-level observational study. Lancet Digit Heal. 2020;2(4):e201-8.

Jiang F, Deng L, Zhang L, Cai Y, Cheung CW, Xia Z. Review of the Clinical Characteristics of Coronavirus Disease 2019 (COVID-19). J Gen Intern Med. 2020;35(5):1545–9.

Zhu N, Zhang D, Wang W, Li X, Yang B, Song J, et al. A novel coronavirus from patients with pneumonia in China, 2019. N Engl J Med. 2020;382(8):727–33.

Chen H, Guo J, Wang C, Luo F, Yu X, Zhang W, et al. Clinical characteristics and intrauterine vertical transmission potential of COVID-19 infection in nine pregnant women: a retrospective review of medical records. Lancet. 2020;395(10226):809–15.

Liu Y, Chen H, Tang K, Guo Y. Clinical manifestations and outcome of SARS-CoV-2 infection during pregnancy. The Journal of infection. 2020. p. 4–11.

Mardani M, Pourkaveh B. A Controversial Debate: Vertical Transmission of COVID-19 in Pregnancy. Arch Clin Infect Dis. 2020;15(1):1–2.

Wang X, Zhou Z, Zhang J, Zhu F, Tang Y, Shen X. A case of 2019 Novel Coronavirus in a pregnant woman with preterm delivery. Clin Infect Dis. 2020 Feb;1:1–3.

Liu W, Wang Q, Zhang Q, Chen L. Coronavirus disease 2019 (COVID-19) during pregnancy: a case series. Preprint. 2020;1(1):1–28.

Liu D, Li L, Wu X, Zheng D, Wang J, Yang L, et al. Pregnancy and Perinatal Outcomes of Women With Coronavirus Disease (COVID-19) Pneumonia: A Preliminary Analysis. AJR Am J Roentgenol. 2020 Mar;1:1–6.

Panahi L, Amiri M, Pouy S. Risks of Novel Coronavirus Disease (COVID-19) in Pregnancy: a Narrative Review. Arch Acad Emerg Med. 2020;8(1):e34.

Rasmussen SA, Jamieson DJ. Coronavirus disease 2019 (COVID-19) and pregnancy: Responding to a rapidly evolving situation. Obstet Gynecol. 2020;135(5):999–1002.

Zhu H, Wang L, Fang C, Peng S, Zhang L, Chang G, et al. Clinical analysis of 10 neonates born to mothers with 2019-nCoV pneumonia. Transl Pediatr. 2020;9(1):51–60.

World Health Organization. Report of the WHO-China Joint Mission on Coronavirus Disease 2019 (COVID-19). WHO. 2020.

American College of Obstetricians and Gynecologists. Novel Coronavirus 2019 (COVID-19). Practice advisory. 2020 [cited 2020 Jun 11]. p. 1.

Kementrian Kesehatan RI. Pedoman Bagi Ibu Hamil, Ibu Nifas, dan Bayi Baru Lahir: Di Era Pandemi COVID-19. Jakarta; 2020.

Capanna F, Haydar A, McCarey C, Bernini Carri E, Bartha Rasero J, Tsibizova V, et al. Preparing an obstetric unit in the heart of the epidemic strike of COVID-19: quick reorganization tips. J Matern neonatal Med Off J Eur Assoc Perinat Med Fed Asia Ocean Perinat Soc Int Soc Perinat Obstet. 2020 Apr;1–7.

Chen D, Yang H, Cao Y, Cheng W, Duan T, Fan C, et al. Expert consensus for managing pregnant women and neonates born to mothers with suspected or confirmed novel coronavirus (COVID-19) infection. Int J Gynecol Obstet. 2020;149(2):130–6.

Qi H, Luo X, Zheng Y, Zhang H, Li J, Zou L, et al. Safe delivery for pregnancies affected by COVID-19. BJOG An Int J Obstet Gynaecol. 2020;1:1–3.

Mirzadeh M, Khedmat L. Pregnant women in the exposure to COVID-19 infection outbreak: the unseen risk factors and preventive healthcare patterns. The journal of maternal-fetal & neonatal medicine. England; 2020. p. 1–2.

Dashraath P, Wong JLJ, Lim MXK, Lim LM, Li S, Biswas A, et al. Coronavirus disease 2019 (COVID-19) pandemic and pregnancy. Am J Obstet Gynecol. 2020;222(6):521–31.

Sass L, Urhoj SK, Kjærgaard J, Dreier JW, Strandberg-Larsen K, Nybo Andersen AM. Fever in pregnancy and the risk of congenital malformations: A cohort study. BMC Pregnancy Childbirth. 2017;17(1):1–9.

Assiri A, Abedi GR, Al Masri M, Bin Saeed A, Gerber SI, Watson JT. Middle East Respiratory Syndrome Coronavirus Infection during Pregnancy: A Report of 5 Cases from Saudi Arabia. Clin Infect Dis. 2016;63(7):951–3.

Zhao Y, Zhao Z, Wang Y, Zhou Y, Ma Y, Zuo W. Single-cell RNA expression profiling of ACE2, the putative receptor of Wuhan 2019-nCov. bioRxiv. 2020;1:1–13.

Li Y, Zhao R, Zheng S, Chen X, Wang J, Sheng X, et al. Lack of Vertical Transmission of Severe Acute Respiratory Syndrome Coronavirus 2, China. Emerg Infect Dis. 2020;26(6):1335–6.

Chen Y, Peng H, Wang L, Zhao Y, Zeng L, Gao H, et al. Infants Born to Mothers With a New Coronavirus (COVID-19). Front Pediatr. 2020;8(March):1–5.

Xu Y, Li X, Zhu B, Liang H, Fang C, Gong Y, et al. Characteristics of pediatric SARS-CoV-2 infection and potential evidence for persistent fecal viral shedding. Nat Med. 2020;26(4):502–5.

Jiehao C, Jing X, Daojiong L, Lei X, Zhenghai Q, Yuehua Z, et al. A Case Series of children with 2019 novel coronavirus infection: clinical and epidemiological features. Clin Infect Dis. 2020;1:1–17.

Centers for Disease Control and Prevention. Interim Guidance for Businesses and Employers Responding to Coronavirus Disease 2019 (COVID-19), May 2020. CDC. 2020 [cited 2020 Jun 11]. p. 1.

American College of Obstetricians and Gynecologists. Coronavirus (COVID-19), Pregnancy, and Breastfeeding: A Message for Patients [Internet]. ACOG. 2020 [diakses tanggal 11 Juni 2020]. p. 1. Tersedia di:

Littauer EQ, Esser ES, Antao OQ, Vassilieva E V., Compans RW, Skountzou I. H1N1 influenza virus infection results in adverse pregnancy outcomes by disrupting tissue-specific hormonal regulation. PLoS Pathog. 2017;13(11):1–27.

Maxwell C, McGeer A, Tai KFY, Sermer M. No. 225-Management Guidelines for Obstetric Patients and Neonates Born to Mothers With Suspected or Probable Severe Acute Respiratory Syndrome (SARS). J Obstet Gynaecol Canada. 2017;39(8):e130-7.

Centers for Disease Control and Prevention. If You Are Pregnant, Breastfeeding, or Caring for Young Children [Internet]. CDC. 2020 [diakses tanggal 11 Juni 2020]. p. 1. Tersedia di:

Radonovich Jr LJ, Simberkoff MS, Bessesen MT, Brown AC, Cummings DAT, Gaydos CA, et al. N95 Respirators vs Medical Masks for Preventing Influenza Among Health Care Personnel: A Randomized Clinical Trial. JAMA. 2019 Sep 3;322(9):824–33.



How to Cite

Hanifa Salma Ramadhani, Nurul Islamy, & Ade Yonata. (2020). COVID-19 in Pregnancy: Is it dangerous?. Medical Profession Journal of Lampung, 10(2), 318-323.




Most read articles by the same author(s)

1 2 > >>